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El Puerto de Santa María is a municipality located on the banks of the Guadalete River in the province of Cádiz, Andalusia.
As of 2009, the city has a population of c. 88,000, of which some 50,000 live in the urban center, and the remainder in the surrounding areas.
The town of El Puerto de Santa María is 10 kilometres (6 miles) north east of Cádiz across the bay of Cádiz and is best known for having been the port from which Columbus sailed on his second voyage to the Americas.